Preventing Future Strokes

    The results of a major, multicenter clinical trial to determine the best treatment for younger patients who have strokes that are potentially due to a hole in the upper chambers of the heart have provided suggestive, but not definitive, evidence of the benefit of a new heart hole-closure device.

    The trial sought to determine which was the best treatment to prevent further strokes: a combination of closing the hole with a “button” device and anti-clotting medicines or anti-clotting medicines alone.

    UCLA was one of the 69 performance sites for the study, called the Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment (RESPECT). Over eight years, the study enrolled 980 patients between the ages of 18 and 60 (average age 46). All had experienced a stroke of unknown origin and had a hole in the wall of their heart known as a patent foramen ovaleor, or PFO. Nearly half had large strokes as their qualifying stroke event. In up to 10 percent of strokes in the U.S., a PFO is the only identified potential cause.

    Patients were followed for an average of two-and-a-half years. In the main analysis, patients assigned to receive the button device showed a trend toward having fewer recurrent strokes than those receiving standard care with anti-clotting medications (9 percent versus 16 percent), but the difference did not meet statistical tests for being definite. Further analyses conducted in the subset of patients who adhered to their assigned treatments provided additional evidence that the device was beneficial.

    Closure-device therapy may be a useful strategy for selected patients with a history of cryptogenic stroke and PFO – a population that is generally younger than the average stroke patient and otherwise facing a lifetime of potentially riskier medications, the UCLA researchers said. The authors said that closing the hole in the heart also has been studied as possibly helping with other health issues, such as migraines.

    “Closure of Patent Foramen Ovale versus Medical Therapy after Cryptogenic Stroke,” New England Journal of Medicine, March 2013

    “Often, one biopsy is not enough to definitively rule out prostate cancer,” says study researcher ...
    Johns Hopkins scientists report that rats exposed to high-energy particles, simulating conditions...
    Is play part of your plan for health? Leisure activities, particularly group activities, are a...
    Experiments in mice with a bone disorder similar to that in women after menopause show that a...
    Photo by Cordero Studios
    Detecting delirium among small patients in the Pediatric Intensive Care Unit is tricky, since...
    Johns Hopkins researchers say they have developed a technique that can predict — with 95 percent...
    Scientists zoom in and out as the brain processes sound Researchers at Johns Hopkins have mapped...
    Brain might be more resilient with advanced schooling Better-educated people appear to be...
    Younger women with diabetes have a higher risk for heart disease Most women will say they want the...
    If you have high cholesterol, then your doctor has surely talked to you about eating right and...