Massachusetts General

Several treatments are on the cusp of FDA approval…
In Alzheimer’s, amyloid-beta protein gets the blame, but is tau the true culprit?
A ductal carcinoma in situ diagnosis can spur premature action, so should it still be called cancer?
A Supreme Court ruling on whether genes can be patented did not give crystal clear answers.
One night a patient got out of bed, fell and hit his head; the incident report that clinicians submitted through the hospital’s patient safety reporting system simply stated that the fall occurred...
During the past 25 years, as mounting research has demonstrated the efficacy of treating patients with means that go beyond a standard physician’s prescription, “integrative medicine” departments...
Eppie Lederer and Pauline Phillips were one of the most famous pairs of identical twins in the United States during the 20th century. Born 17 minutes apart, both women became wildly popular...
Xiaowei Zhuang couldn’t believe what she was seeing. Utilizing super-resolution microscopy techniques she had developed, Zhuang, a Harvard University biophysicist and chemical biologist, was trying...
I t’s a sad fact of modern medicine that many diseases—cancer, Alzheimer’s, Parkinson’s—remain difficult to treat. But for many of the most prevalent disorders, chronic diseases that affect large...
Nine-year-old Shan Rée of West Vancouver, British Columbia, was no stranger to hospitals. Since infancy, she had been admitted two or three times a year for the intravenous antibiotics and intensive...
Bloodless surgery is something of a misnomer. There’s bound to be bleeding, even when an operation is performed using minimally invasive techniques that require only small incisions. What bloodless...
M uch of what science knows about the human brain has come through deduction. If a stroke or trauma has destroyed a particular area, researchers can look at what that person can no longer do—talk,...
O n December 28, 1981, two days before his 71st birthday, gynecologic surgeon Howard Jones wrote a news release he hoped he wouldn’t have to use. The first baby created by in vitro fertilization in...
U sing breath to divine the inner workings of the human body is a practice as ancient as Hippocrates, who described the fetor hepaticus of liver failure that manifested itself in the fishy odor of...
Aging nuclear reactors often struggle to stay on line, a fact that’s just as true for small research reactors as it is for massive power plants. So it shouldn’t have been surprising that during 2008...
There’s a long and winding road to Food and Drug Administration approval for a new drug. First the medication has to be tested in animals, followed by three phases of human clinical trials with...
D ruing the late 1990s, Linda Griffith was working in the laboratory of Joseph Vacanti, a pioneer in the field of tissue engineering, when she had a revelation. Vacanti, Griffith and their colleagues...
Its nine million members make Kaiser Permanente a giant of American health care. They also put the health maintenance organization in a position to create one of the nation’s most expansive...
In this era of cancer genetics, we’ve come to think of cancer as something like a car. Runaway cell proliferation is driven by accelerators, or oncogenes, that are stuck on go—in collusion with...
Almost 100 years ago, in a Paris laboratory, Félix d’Hérelle peered at cultures packed with dysentery bacteria. He had cultured the organisms from the stool of people with the disease, and usually...
Developing a malaria vaccine is a particularly knotty problem: Vaccines typically can target only one or a few antigens—proteins produced by infectious organisms, against which the host’s immune...
About one in five prescriptions is “off label”—that is, a drug prescribed to treat a condition for which it hasn’t been approved by the Food and Drug Administration. That’s a legal option for...
It takes only a few hours to have an implantable cardioverter defibrillator (ICD) placed in your chest. During the procedure, which may be performed under local anesthesia and a sedative, the...
As the nation’s healthcare system strains to manage a sour economy and an aging population, large academic medical centers like Massachusetts General Hospital are on the hot seat to cut costs. In the...
BOSTON – For the first time, Massachusetts General Hospital (MGH) researchers have isolated egg-producing stem cells from the ovaries of reproductive age women and shown these cells can produce what...
The initial clinical trial of a novel approach to treating amyotrophic lateral sclerosis – blocking production of a mutant protein that causes an inherited form of the progressive neurodegenerative...
MGH investigators have determined that one of the recently identified genes contributing to the risk of late-onset Alzheimer's disease regulates the clearance of the toxic amyloid beta (A-beta)...
Thomas Gagnon arrived at Massachusetts General Hospital expecting to receive a kidney transplant. Instead, he was referred to the Mass General Weight Center for life-changing obesity treatment.
Adding the dietary supplements folate and vitamin B12 to treatment with antipsychotic medication improved a core symptom component of schizophrenia in a study of more than 100 patients.
A new approach to investigating hard-to-find chromosomal abnormalities has identified 33 genes associated with autism and related disorders, 22 for the first time. Several of these genes also appear...

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