The margarita is one of the world’s most famous cocktails, and it lends itself to experimentation like no other. Whether you’re throwing an epic cookout or just chilling around your pool, spice things up and try a new variation on the classic cocktail. We asked a few of America’s best bartenders to share their ideas for delicious twists, infused with interesting flavors—from bitter to honey, tropical fruit to hot spice. There’s even one featuring sotol—a newly exported cousin of our favorite Mexican spirit, made from the desert spoon plant. Salud!