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Sylva Yepremian’s Sylva & Cie. jewelry (www.sylvacie.com) combines refined old-world craftsmanship with such avant-garde materials as large, rough-diamond rocks and bright-colored opals. Striking new designs from the Los Angeles–based designer, who launched her brand three years ago, include a large purplish Australian opal ring surrounded by twin diamond-encrusted serpents. Another ring features an intricate rose-gold setting with a rough-gray-diamond center. Yepremian, who learned the trade from her father—a master jeweler at Cartier—oversees the handcrafting of each design ($1,000 to $50,000) in her downtown studio.

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