Zurich, the Swiss city known for finance and buttoned-up formality, is loosening its tie and showing its edgy side. Leading the way in the city’s cooldown are new and established hotels that are breaking with stuffy traditions. Among the unorthodox newcomers is Kameha Grand Zürich (kamehagrandzuerich.com), an Autograph Collection hotel that opened in 2015 in the emerging Glattpark district. Conceived by the design world’s enfant terrible, Marcel Wanders, the hotel is a veritable wonderland of avant-garde style, featuring cheeky nods to Swiss culture such as lamps that resemble oversize cow bells and sofas shaped like giant Toblerone bars. Last spring, the 95-room Atlantis by Giardino (atlantisbygiardino.ch) made its debut in one of Switzerland’s most important postwar modernist buildings. The Los Angeles–based firm Hirsch Bedner Associates adorned the interiors of the Y-shaped structure with furnishings by Patricia Urquiola, Armani/Casa, and Brabbu; outside, a swimming pool at the foot of the Üetliberg mountain offers a laidback spot for a swim. Zurich’s legendary Dolder Grand has also joined the movement with the debut of its Saltz restaurant (thedoldergrand.com), a vibrant red-and-blue venue designed by the artist Rolf Sachs. And bringing a modern edge to Old Town is the Marktgasse Hotel (marktgassehotel.ch), a 39-room boutique property blending Scandinavian minimalism and Italian maximalism in a pair of 15th-century structures.