The sleek St. Regis, San Francisco is a composition of clean lines and elemental materials with a subtle Asian flair. The property is cutting-edge, international, and full of surprises. Modern amenities abound, including high-speed wireless Internet access and “digital assistants” in each room that control lights, blinds, and audio/video systems. Accommodations Each of the 260 guest rooms features leather-textured walls and oversize soaking tubs. Facilities Remède Spa awaits those who wish to be pampered in a tranquil, Zen-like environment. Dining Appetites can be satisfied at Ame, the innovative American-style restaurant with a Japanese twist by Hiro Sone and Lissa Doumani, who are best known for Napa Valley’s celebrated Terra. Worthy Diversion Shopping in Union Square is a ten-minute walk; the financial district is best accessed by a quick trolley ride. Rates From $400; the 3,200-square-foot Presidential Suite is available for $9,000.